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王栋
2023-02-12 14:40  

    名:王栋

职称/职务:教授,博士生导师, 执业药师

     业:有机化学            

研究方向:含氮杂环的有机合成方法学,药物设计与合成

联系方式:vinigrol (微信号)

   箱:chem_wd@hotmail.com

  室:新疆大学博达校区药学院208A房间

课题组网站:https://www.x-mol.com/groups/wang_dong

个人经历。。。。              。。。。。。。。。。。。。。。。。。。。。。。。

学习经历:

2006 -2011  美国路易斯安那州立大学,有机化学专业,哲学博士

2003-2006  北京理工大学,应用化学专业,工学硕士

1999-2003  北京理工大学,化学工程与工艺专业,工学学士

工作经历:

2022.05-至今: 新疆大学,药物研究所,副所长

2021.12-至今: 新疆大学,化学学院,教授

2021.01-2021.12:新疆大学,化学学院,副教授

2014.12-2020.12:天津科技大学,生物工程学院,副教授

2012.08-2014.12天津长森药业有限公司,助理主任

2011.05-2012.08天津药明康德新药开发有限公司,合成部组长

主讲课程                                          

本科生:《有机化学》,《有机化学实验》,《天然药物化学》,《药物合成反应》,《制药工程原理》,《有机合成路线设计》

研究生:《高等药物分析》,《高等有机合成》

主持科研项目                                          

1. 国家自然科学基金项目, 22261051, 吡啶及喹啉C3-H/C4-H键官能团化反应研究与应用, 2023/01-2026/12, 33万元,在研,项目负责人。

2.  新疆杰出青年科学基金项目,2022D01E34,3-取代吡啶衍生物催化合成反应研究,2022/12-2025/12, 50万元,在研,项目负责人。

3. 国家重点研发计划项目,2018YFA0901701,非细胞生物合成系统的构建与应用-子课题:人工辅酶设计及其协同催化,2019/07-2024/06, 89万元,在研,子课题负责人。

4. 横向项目(山西集翔生物工程有限公司),降低原料药核黄素磷酸钠中杂质含量的工艺研究,2019/01-2020/12, 10万元,在研,项目负责人

5. 天津市应用基础及前沿技术研究计划项目,15JCYBJC53400,双环[n.3.1]烷酮类化合物的合成方法研究及应用,2015/11-2018/10, 10万元,已结题,项目负责人

6. 天津市教委科研计划项目,2017KJ008, 8-氮杂香豆素衍生物的合成及构效关系研究, 2017/05-2020/046万元,已结题,项目负责人

奖励情况:                                        

2002年获得北京理工大学优秀学生奖;

2009年获得美国路易斯安那州立大学化学系优秀助研奖;

2010年获路易斯安那州立大学Coates会议奖;

2012年在药明康德新药开发有限公司晋升测试I中获得优秀成绩;

2013年获得天津经济技术开发区高级人才证书;

2014年获得萃智创新工程师称号

2021年获得新疆大学青年教师教学竞赛优秀奖;

2022年获得Wiley出版社颁发的年度论文高下载次数奖

社会工作                                      

中国化学会会员(2018-

美国化学会会员(2010-

研究生教育评估监测专家库专家 (2022-)

执业药师(2021-

Frontiers in Chemistry期刊评审编辑(2022-)

JOC, OL, Green Chem, Adv. Synth. Catal., OBC, TL, EJMC等期刊审稿人

代表性研究成果                                

以第一作者或第一通讯作者先后发表各类科研论文30余篇(含一区论文11篇,2 篇影响因子10 以上的论文、3篇封面论文、1VIP论文以及2 篇综述),第一发明人授权发明专利5项。发表的主要学术论文有:

1. Dong Wang*, Liqing Xu,Shixin Zheng and Xiaolong Yang. Transition-Metal-Free Regioselective Direct C2, C4 Difunctionalization and C2, C4, C6 Trifunctionalization of Pyridines. Advanced Synthesis & Catalysis2022, 364 (16), 2720-2728.

2. Shixin Zheng, Dong Wang*, Mindong Huang and Peng Yu*. Rapid Generation of Tetrahydropyridines and Tetrahydroquinolines by Dearomative Cyanation/Grignard Addition. Chemistry-An Asian Journal, 2022, 17, e202200077.

3. 王栋,阿布力米提·阿布都卡德尔。基于粉笔教学的有机化学教学改革,广东化工2021,48 (8), 294-295.

4. Dong Wang*, Laurent Désaubry, Gaoyu Li, Mindong Huang and Shixin Zheng. Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N-oxide Chemistry. Advanced Synthesis & Catalysis, 2021, 363 (1), 2-39.

5. Dong Wang, Redouane Tabti, Sabria Elderwish, Amel Djehal, Nora Chouhad, Franck Pinot, Peng Yu, Canan G. Nebigil, Laurent Désaubry. SFPH proteins as therapeutic targets for a myriad of diseases. Bioorganic & Medicinal Chemistry Letters, 2020, 30 (22), 127600.

6. Xin Jin, Jianling Xie, Michael Zabolocki, Xuemin Wang, Tao Jiang, Dong Wang, Laurent Désaubry, Cedric Bardy, Christopher G Proud. The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis. Journal of Biological Chemistry, 2020, 295(29), 9855-9867.

7. Tian Zhao, Yujie Liu, Yanfei Hao, Wei Zhang, Li Tao, Dong Wang, Yuyin Li, Zhenxing Liu, Edward A McKenzie, Qing Zhao*, Aipo Diao*. Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Investigational New Drugs, 2021, 39, 337-347.

8. Dong Wang*, Mindong Huang, Gaoyu Li, Shixin Zheng, Peng Yu. Scalable Synthesis of a Tetrasubstituted 7-Azabenzofuran as a Key Intermediate for a Class of Potent HCV NS5B Inhibitors. Tetrahedron, 2020, 76 (48), 131642.

9. Linru Dong, Xinyue Ma, Yu Fan, Dong Wang*. A One‐Pot Dearomative Approach to C4‐Alkylated Tetrahydropyridines and Tetrahydroquinolines. Asian Journal of Organic Chemistry, 2020, 9(10), 1571-1575.

10. Lianbo Zhao, Lei Hao, Yupeng Fu, Yan Cheng, Guojun Pan, Laurent Désaubry, Peng Yu*, Dong Wang*. Accessing 1,8-Naphthyridones by Metal-Free Regioselective Amination of Pyridine N-oxides/Acid-Mediated Cyclization. Advanced Synthesis & Catalysis, 2020, 362, 3841-3845.

11. Dong Wang*, Yu Fan, Peng Yu and Laurent Désaubry*.Recent advances in the synthesis of 2,3-dihydropyrroles. Chemical Communications, 2020, 56, 5584-5592.

12. Chunsheng Fu, Gaoyu Li, Meng Shen, Longxia Zhang, Peng Yu and Dong Wang*. Facile and Efficient Synthesis of Tri- and Tetrasubstituted 7-Azabenzofuran Derivatives. Asian Journal of Organic Chemistry, 2020, 9(5), 749-752.

13. Dong Wang*, Yuanyang Jiang, Linru Dong, Gaoyu Li, Baoying Sun, Laurent Désaubry and Peng Yu. One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines. Journal of Organic Chemistry, 2020, 85(7), 5027-5037. (Selected as Front Cover Paper)

14. Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil and Laurent Désaubry*. Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases. Cellular and Molecular Life Sciences, 2020, 77, 3525-3546.

15. Dong Wang*, Xinyue Ma, Linru Dong, Hairong Feng, Peng Yu and Laurent Désaubry*. Stereoselective four-component synthesis of functionalized 2,3-dihydro-4-nitropyrroles. Frontiers in Chemistry, 2019, 7:810, doi: 10.3389/fchem.2019.00810.

16. Dong Wang*, Zhentao Wang, Zhenlin Liu, Mindong Huang, Jianyong Hu, and Peng Yu*. Strategic C-C bond-forming dearomatization of pyridines and quinolines. Organic Letters, 2019, 21(12), 4459-4463.

17. Dong Wang*, Zhenlin Liu, Zhentao Wang, Xinyue Ma, and Peng Yu*.Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides. Green Chemistry, 2019, 21 (1), 157-163.

18. Amel Djehal, Mohammad Krayem, Ahmad Najem, Hassan Hammoud, Thierry Cresteil, Cannon Nebigil, Dong Wang, Peng Yu, Embak Bentouhami, Ghanem Ghanem, Laurent Désaubry*.  Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells. European Journal of Medicinal Chemistry, 2018, 155, 880-888.

19. Dong Wang, Linna Li, Hairong Feng, Hua Sun, Fabrice Almeida-Veloso, Marine Charavin, Peng Yu, Laurent Désaubry*. Catalyst-free three component synthesis of highly functionalized 2,3-dihydropyrroles. Green Chemistry, 2018, 20 (12), 2775-2780.

20. Dong Wang*, Jianyong Hu, Junjie Zhao, Meng Shen, Yuxi Wang, and Peng Yu*. Transition-metal-free access to 7-azaindoles. Tetrahedron, 2018, 74 (30), 4100-4110.

21. Dong Wang*, Meng Shen, Yuxi Wang, Jianyong Hu, Junjie Zhao, and Peng Yu*. Access to Furo[2,3-b]pyridines by Transition-Metal-Free Intramolecular Cyclization of C3-substituted Pyridine N-oxides. Asian Journal of Organic Chemistry, 2018, 7(5), 879-882.

22. Dong Wang*, Hairong Feng, Linna Li, Zhenlin Liu, Zhongli Yang, and Peng Yu*. Access to 8-Azachromones via Activation of C-H in N-Oxides. Journal of Organic Chemistry, 2017, 82(20), 11275-11287.

23. Dong Wang*, Yuxi Wang, Junjie Zhao, Meng Shen, Jianyong Hu, Zhenlin Liu, Linna Li, Furen Xue, and Peng Yu*.Strategic Approach to 8-Azacoumarins. Organic Letters, 2017, 19(5), 984-987.

24. Dong Wang*, Longfei Miao, Lixia Feng, Qingwei Yao, Gnel Mkrtchyan, William E. Crowe, Evgueni E. Nesterov, Yuekui Wang, Xiaoting Zhang and Peng Yu*.Mechanism and origin of stereoselectivity in Robinson annulations leading to bicyclo[3.3.1]nonanes: a rare Curtin–Hammet scenario. Journal of Physical Organic Chemistry, 2017, 30: e3595. DOI: 10.1002/poc.3595.

25. Dong Wang*, Junjie Zhao, Yuxi Wang, Jianyong Hu, Linna Li, Longfei Miao, Hairong Feng, Laurent Désaubry, and Peng Yu*. A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N-Oxides. Asian Journal of Organic Chemistry, 2016, 5(12), 1442-1446. (Selected as Front Cover Paper)

26. Hua Sun, Yazhou Zhang, Weina Ding, Xue Zhao, Xiaotong Song, Dong Wang, Yashan Li, Kailin Han, Yang Yang, Ying Ma, Runling Wang, Dong Wang*, Peng Yu*.Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry, 2016, 123(10), 365–378.

27. Dong Wang*, Yuxi Wang, Junjie Zhao, Linna Li, Longfei Miao, Dong Wang, Hua Sun and Peng Yu*. A Highly Practical and Convenient Halogenation of Fused Heterocyclic N-oxides. Tetrahedron, 2016, 72(38), 5762-5768.

28. Dong Wang*, William E. Crowe. A facile approach to tricyclo[6.4.0.04,9]-dodecane framework. Chinese Chemical Letters, 2015, 26(2), 238-242.

29. Dong Wang*, Hailing Jia, Wuchang Wang and Zhe Wang. A practical and mild chlorination of fused heterocyclic N-oxides. Tetrahedron Letters, 2014, 55(51), 7130-7132.

30. Dong Wang and William E. Crowe*. One-Carbon Bridge Stereocontrol in Robinson Annulations Leading to Bicyclo[3.3.1]nonanes. Organic Letters, 2010, 12(6), 1232-1235.

31. Dong Wang, William E. Crowe*, Robert M. Strongin and Martha Sibrian-Vazquez.Exploring the pH dependence of viologen reduction by α-carbon radicals derived from Hcy and Cys. Chemical Communications, 2009, 14, 1876-1878.

已授权专利:

1. 王栋,王喆,浩日沁巴图。黄藤素及其类似物的制备方法。中国专利,2014,公开号:CN 103980271A.

2. 王栋,郁彭,滕玉鸥,王玉玺,赵俊杰,沈蒙,胡健湧,刘振林,张倩,袁媛,陈文竹。一种8-氮杂香豆素的合成方法及其在抗肿瘤药物中的应用。中国专利,2019/03,已授权。公开号:CN106810560A。专利号:ZL201611202287.1

3. 王栋,郁彭,德奥希里•洛朗, 李林娜,孙华。新型五取代2,3-二氢吡咯衍生物及其制备方法和应用。中国专利,2017/10,已授权。公开号:CN107721895A。授权日:2020/03/20, 专利号:ZL201710952997.4

4. 王栋,郁彭,胡健湧,马欣悦。一种哮喘药物Fevipiprant的简洁合成方法。中国专利,2018/02,已授权。专利号:ZL201810161042.1

5. 王栋,郁彭,刘振林,王振涛。2-吡啶甲基硫醚的合成方法及相关药物的合成工艺。中国专利,2018/09, 已授权。专利号:ZL201811091737.3

6.王栋,李高宇,郑世鑫,崔姗姗,丁颖,崔丽,滕玉鸥,郁彭。一类7-氮杂苯并呋喃衍生物及其在抗肿瘤药物中的应用。中国专利,2020/10, 已授权。专利号:ZL202011100856.8

7. 郁彭,王栋,滕玉鸥,苗龙飞,王静,张倩,袁媛。一种新型水溶性靛红衍生物及其制备方法与应用。中国专利,2016/07,已授权,专利号:ZL201610589432.X。世界专利,2018/01,公开号:WO2018014368A1。美国专利,公开号:US 20190359568A1, 专利号:107037172019/11/28公开, 2020/03/04授权。

8.     郁彭,王栋,刘振林,赵俊杰,李林娜,冯海荣。一种8-氮杂色酮的合成方法。中国专利,2017/07,已授权。专利号:201710595269.2

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