硕士生导师

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范仲雄 副教授

发布日期:2023-01-13浏览次数:

AAC8

姓 名:范仲雄

职 称:副教授

专 业:高分子化学与物理

研究方向:功能性纳米材料的理性设计

招生方向:生物化学与分子生物学(学术型硕士研究生);制药工程(专业型硕士研究生)

邮 箱:fanzhongxiong@xju.edu.cn


教育背景

2018年09月-2022年06月:厦门大学,博士。

讲授课程

本科生:《药学概论》、《药剂学》、《制药工程伦理学》、《生物工程设备》、《工厂设计与CAD》、《纳米科学与纳米技术》

研究生:《高级生物化学》、《现代微生物学研究技术》、《高等药剂学》、《药物代谢》


科研项目

1.国家自然科学基金项目,2026/1-2029/12,在研,主持。

2.新疆维吾尔自治区重点研发专项,2023/12-2026/12,在研,首席。

3.2024年科普中国高校行项目(第二批),2024/8-2025/4,已结题,主持。

4.2022年度自治区“天池英才”引进计划-青年博士项目,2023/01-2026/1,在研,主持。

5.新疆维吾尔自治区重点研发专项,2024/12-2027/12,在研,主持。

6.新疆维吾尔自治区青年科学基金,2022/12-2025/12,在研,主持。

7.新疆维吾尔自治区高校基本科研业务费科研项目-培育类项目,2023/6-2026/6,在研,主持。

8.新疆维吾尔自治区重点实验室开放课题,2023/8-2025/12,在研,主持。

9.新疆中药制剂循证与转化重点实验室开放课题,2025/1-2027/12,在研,主持。

10.横向课题2项,在研,主持。


荣誉与奖励

1.2024年获自治区第一届博士后创新创业大赛优胜奖(负责人)

2.2024年指导本科生参与生命科学竞赛获全国三等奖和自治区二等奖

3.2023年指导本科生获生命科学竞赛全国二等奖和自治区一等奖

4.2023年指导本科生获批国家级大学生创新训练计划项目

5.2024年指导本科生获批国家级大学生创新训练计划项目

6.2022年获得厦门大学优秀毕业生荣誉称号

7.2022年获得厦门大学本栋奖学金

8.2020年、2021年、2022年获得厦门大学校级“优秀三好学生”荣誉称号

9.2021年获得厦门大学材料学院优秀共产党员荣誉称号

10.2019年获得厦门大学中国航天科技集团公司CASC公益奖学金

11.2016年获得硕士研究生国家奖学金

12.2015年获得新疆维吾尔自治区学位委员会优秀论文奖


社会工作

1.厦门大学新疆校友会第三届理事会常务理事、副会长

2.《Exploration》和《国际生物医学工程杂志》编委

3.教育部学位论文评审专家

4.中国中医药信息学会常务理事

5.中国生物物理学会纳米生物学分会委员

6.中国心血管药理学专业委员会第三届青年委员会委员

7.中国药理学会神经精神药理学专业委员会第二届青年委员会委员

8.中国卒中学会第三届委员会委员

9.中国卒中学会新药研发与评价分会第三届青年委员会委员

10.中国实验动物学会屏障医学专业委员会学术委员会委员

11.新疆佳音医院学术委员会委员

12.审稿专业期刊20余本


代表性研究成果

已在Adv. Funct. Mater.Chem. Eng. JBiomaterials.Anal. Chem.J. Nanobiotechnol.Nano Res.Mater. Today Bio.等国际高水平期刊发表SCI论文50余篇,H-index 30,授权国家专利3项。审稿高水平专业期刊20余本,作为执行主席主办国际会议1次、协助组织全国性学术会议2次,重要学术会议做大会报告10次。在新疆地区组织科普宣讲/义诊10场/次。已发表主要学术论文如下:

1.Xia,G.‡;Fan, Z.‡*;Wang, Q.; Li, J.; Zhang, Y.; Adila, A.; Su, Q.; Li, Ying.; Hou, Z.*; Li, J.*Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy.J. Nanobiotechnol.,2025,23(1): 167(JCR 1区.当年影响因子:12.6)

2.Tan, X.; Li, Y.; Jin, H.; Zhou, Y.; Li, W.; Zhao, Y.; Hai, J.; Li, J.;Fan, Z.*; Yang, L.*Metformin-induced precise targeted inhibition of ischemic neuronal death by a programable endogenous ROS-responsive nanoprodrug.Chem. Eng. J,2025,512:162106.(JCR 1区.当年影响因子:13.4)

3.Gao, F.;Lin,W.;Zhao,T.;Zhang, J.; Pei, D.; Di, D.;Fan, Z.‡*;Yang, L.; Hai, J.Visualwhole-processmonitoringdynamicphaseseparation ofautophagiclysosomes in Alzheimer’s Disease by alysosome-targeted pH-activatedfluorescenceprobe.Anal. Chem., 2025,https://doi.org/10.1021/acs.analchem.5c02994(JCR 1区.当年影响因子:6.7)

4.Chen, K.;Zhang, Y.;Fan, Z.‡*; Zhu, J.; Xu,Q.; Xu, J*. Valence electronic modulation induced by reinforcing interfacial coupling for expediting sulfur redox in Li-S batteries.Adv. Funct. Mater.2025,2500574.(JCR 1区.当年影响因子:19.0)

5.Zhang, J.; Jing, Q.; Yuan, L.; Zhou, X.; Di, D.; Li, J., Pei, D.;Fan, Z.*; Hai, J.* NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD.Mater. Today Bio.,2025, 31: 101540-101540.(JCR 1区.当年影响因子:10.6)

6.Fu, X.; Zhao, L.; Yin, W.; Hou, S.; Liu, H.; Kou, L.;Fan, Z.*; Zhang, D.*, Redox-responsive self-targeting carrier-free nanotherapeutic agent with ROS storm for enhancing tumor oxidative stress.Colloids Surf. B., 2025, 256: 115069.(JCR 1区.当年影响因子:5.6)

7.Jing,Q.;Zhang,J.;Yuan,L.; Zhang, H.; Lin, W.; Pei, D.; Di, D.; Yang, L.;Fan,Z.*;Hai,J.*Copper-basedhollowmesoporousnanogenerator withreactiveoxygenspecies andreactivenitrogenspeciesstormgeneration forself-augmentedimmunogeniccelldeath-mediatedtriple-negativebreastcancerimmunotherapy.J. Colloid Interface Sci.,2025,688, 688-702(JCR 1区.当年影响因子:9.4)

8.Fan, Z.‡; Jin, H.‡; Tan, X.‡; Li, Y.‡; Shi, D.; Wang, Q.; Meng, J.; Li, W.; Chen, C.; Peng, L.; Hou, Z.; Li, J.*; Jin, X.*; Yang, L.*ROS-responsivehierarchicaltargetingvehicle-freenanodrugs forthree-pronged Parkinson'sdiseasetherapy.Chem. Eng. J,2023,466:143245.(JCR 1区.当年影响因子:16.744)

9.Fan, Z.‡; Ren, T.‡; Wang, Y.‡; Jin,H.; Shi,D.; Tan,X.; Ge,D.; Hou,Z.;Jin. X.; Yang. L.*Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβclearance.Biomaterials.,2022, 283: 121452.(JCR 1区.当年影响因子:15.304)

10.Fan, Z.‡;Xia,G.‡;Zhu,F.‡;Yang, N.;Ma,A.;Shi,Y.;Jiang,Z.; Zhou, X.; Hou,Z.*Ruthenium-quercetin coordinated nanotherapeutics with macrophage polarization regulation to rapidly promote bacterial-infected wound healing.Mater. Today Bio.,2025, 31: 101540-101540.(JCR 1区.当年影响因子:10.6)

11.Liu. H.; Zhuo. R.; Zou. C.; Xu. S.; Cai. X.; Ge. Y.; Liu. G.; Wu. C.; Dai. C.; Li. J.; Xu. S.;Fan, Z.*;Yang, L.;Li, Y.*RVG-peptide-camouflaged iron-coordinated engineered polydopamine nanoenzyme with ROS scavenging and inhibiting inflammatory response for ischemic stroke therapy.Int. J. Biol. Macromol.,2024, 282: 136778.(JCR 1区.当年影响因子:7.7)

12.Fan, Z.; Zhu, F.; Wu, F.; Yang, N.; Ma, A.; Bai, W.; Jiang, Z.; Hou, Z.*; Zhou, X.*Self-targeting carrier-free coordination nanotherapeutics for tumor microenvironment modulation and enhanced chemo-dynamic oncotherapy.Colloids Surf. B.,2025, 256:114980.(JCR 1区.当年影响因子:5.6)

13.Fan, Z.; Ma,A.; Zhu, F.; Meng,J.; Yang,N.; Ma, W.; Jiang, Z.; Hou, Z.*; Zhou, X.*Carrier-free metal-organic nanodrugs via coordination-driven self-assembly for synergistic anti-angiogenesis and oxidative-stressoncotherapy.Nano Res.,2025,18: 94908073.(JCR 1区.当年影响因子:5.6)

14.Zhang,X.;Zhang,K.;Liu,K.;Yu,S.;Fu,X.;Yuan,Q.;Zhu,C.;Lin,D.*;Fan, Z.*A novel supramolecular nanodrugs for improving the cognitive function of schizophrenia by protecting active lactone of arecoline.Biomed.Pharmacother.,2025, 183:117845-117845.(JCR 1区. IF:7.5)

15.Fan, Z.; Jiang, B.; Zhu, Q.; Xiang, S.; Tu, L.; Yang, Y.; Zhao, Q.; Huang, D.; Han, J.; Su, G.; Ge, D.; Hou, Z. Tumor-specific endogenous FeII-activated, MRI-guided self-targeting gadolinium-coordinated theranostic nanoplatforms for amplification of ROS and enhanced chemodynamic chemotherapy.ACS Appl. Mater. Interfaces.,2020,12(13):14884-14904.(JCR 1区.当年影响因子:10.383)

16.Shi, D.; Wu, F.; Huang, L.; Li, Y.; Ke S.*; Li, J.*; Hou, Z.*;Fan, Z.* Bioengineered nanogenerator with sustainable reactive oxygen species storm for self-reinforcing sono-chemodynamic oncotherapy.J. Colloid Interface Sci.2023, 603:70-84.(JCR 1区.当年影响因子:9.965)

17.Fan, Z.; Shi, D.; Zuo, W.; Feng. J.; Ge. D.; Su. G.;* Yang. L.;* Hou. Z.* Trojan-horsediameter-reduciblenanotheranostics formacroscopic/microscopic imaging-monitoredchemo-antiangiogentictherapy.ACS Appl. Mater. Interfaces.,2022, 14 (4):5033-5052.(JCR 1区.当年影响因子:10.383)

18.Wang, Q.; Meng, J.; Huang, L.; Wu, F.; Yi, X.; Su, G.; Li, Y.*; Hou, Z.*;Fan, Z.* Platinum-coordinatedengineerednanoreactors with O2self-amplificationand on-demandcascadechemo-drugsynthesis forself-reinforcinghypoxiconcotherapy.ACS Appl. Mater. Interfaces.,2023, 15 (14):17495-17506.(JCR 1区.当年影响因子:10.383)

19.Fan, Z.; Wang, Y.; Xiang, S.; Zuo, W.; Huang, D.; Jiang, B.; Sun, H.; Yin, W.;* Xie, L.;* Hou, Z.* Dual-self-recognizing, stimulus-responsive and carrier-free methotrexate–mannose conjugate nanoparticles with highly synergistic chemotherapeutic effects.J. Mater. Chem. B.,2020, 8(9):1922-1934.(JCR 1区.当年影响因子:7.571)

20.Huang, L.; Wu, F.; Wang, Q.; Meng, J.; Feng, J.; Su, G.*; Yi, X.; Li, Y.*; Li, J.-Y.*; Hou, Z.*;Fan, Z.* TME-triggeredcopper-coordinatedengineeredprogrammablenanogenerators for on-demandcascade-amplifyingoxidativestress.J. Mater. Chem. B.,2023,11 (16):3679-3692(JCR 1区.当年影响因子:7.571)

21.Yang, Q., Ye, W.; Luo, D.; Xing, J.; Xiao, Q.; Wu, H.; Yao, Y.; Wang, G.; Yang, L.; Guo, D.; Wang, K.; He, Y.; Ye, X.; Zhang, J.; Jing, Z.;Fan, Z.*; Wen, X.; Mao, J.; Chen, X.; Zhao, Q.*Neuroprotectiveeffects ofanti-TRAIL-ICGnanoagent and itsmultimodalimagingevaluation incerebralischemia-reperfusioninjury.Mater. Today Bio.,2024, 26:101094(JCR 1区.当年影响因子:8.2)

22.Zhuo, R.; Song, Z.; Wang, Y.; Zhu, M.; Liu, F.; Lin, P.; Rao, R.; Zhou, Y.; Zhao, Y.;Fan, Z.*; Cui, L.; Liu, H.; Li, J.; Li, Y.; Guo, H.; Cai, C. F.; Yang, L.*, Oleoylethanolamide ameliorates motor dysfunction through PPARα-mediates oligodendrocyte differentiation and white matter integrity after ischemic stroke.Phytotherapy Research,2023, 37: 5341-5353.(JCR 1区.当年影响因子:7.5)

23.Song, M.; Aipire, A.; Dilxat, E.; Li, J.; Xia, G.; Jiang, Z.;Fan, Z.*; Li, J.*, Research progress of polysaccharide-gold nanocomplexes in drug delivery.Pharmaceutics,2024, 16:88.(JCR 1区.当年影响因子:5.400)

24.Yu, S.; Xia, G.; Yang, N.; Yuan, L.; Li, J.; Wang, Q.; Li, D.; Ding, L.; Fan, Z.*; Li, J.* Noblemetalnanoparticle-basedphotothermaltherapy:development andapplication ineffectivecancertherapy.Int. J. Mol. Sci.2024, 25(11):5632.( JCR 1区.当年影响因子:5.6)

25.Yang, N.; Li, J.; Yu, S.; Xia, G.; Li, D.; Yuan, L.; Wang, Q.; Ding, L.;Fan, Z.*; Li, J.* , Application ofnanomaterial-basedsonodynamictherapy intumortherapy.Pharmaceutics,2024, 16:603.(JCR 1区.当年影响因子:5.4)

26.Wang, Q.; Xia, G.; Li, J.; Yuan, L.; Yu, S.; Li, D.; Yang, N.;Fan, Z.*; Li, J. Multifunctional nanoplatform for NIR-II imaging-guided synergistic oncotherapy.Int. J. Mol. Sci.2023, 24:16949.(JCR 1区;当年影响因子:5.6)

27.Chen, K.; Lin, Z; Zhang, G.; Zheng, J.;Fan, Z.*; Xiao, L.; Xu, Q.; Xu, J.* Efficienthostmaterials forlithium-sulfurbatteries:ultrafine CoPnanoparticles inblackphosphorus-carboncomposite.ChemSusChem,2024, 17 (14): e202400339.(JCR 1区.当年影响因子:8.4)

28.Li, Y.; Wu, C.; Yang, R.; Tang, J.; Li, Z.; Yi, X.; Fan, Z. Application anddevelopment ofcellmembranefunctionalizedbiomimeticnanoparticles in thetreatment ofacuteischemicstroke.Int. J. Mol. Sci.,2024, 25:8539.(JCR 1区;当年影响因子:5.6)

29.Fan, Z.*;Xia, G.; Wang, Q.; Chen, S.; Li, J.; Hou, Z.; Jiang, Z.; Feng, J*.Endogenous Fe2+-triggered self-targeting nanomicelles for self-amplifying intracellular oxidative stress.Anim Models Exp Med.,2024,8 (2): 307-321.(JCR2区;当年影响因子:3.8)

30.Li, W.; Zhang, H.; Xu, J.; Maimaitijiang, A.; Su, Z.; Fan, Z.; Li, J. Thebiologicalroles of ZKSCAN3 (ZNF306) in thehallmarks ofcancer:frommechanisms totherapeutics.Int. J. Mol. Sci.,2024, 25:11532.(JCR 1区;当年影响因子:5.6)

31.Fan, Z.; Jiang, B.; Shi, D.; Yang, L.; Yin, W.; Zheng, K.; Zhang, X.; Xin, C.; Su, G.*; Hou, Z.*, Selective antitumor activity of drug-free TPGS nanomicelles with ROS-induced mitochondrial cell death.Int. J. Pharm.,2021, 594:120184.(JCR 1区.当年影响因子:6.510)

32.Maimaitijiang, A.; He, D.; Li, D.; Li, W.; Su, Z.; Fan, Z.; Li, J. Progress in research of nanotherapeutics for overcoming multidrug resistance in cancer.Int. J. Mol. Sci.,2024, 25: 9973.(JCR 1区;当年影响因子:5.6)

33.Zhang, X.; Zhu, X.; He, Y.; Zhang, Y.*; Huang, S.; Yi, X.; Li, Y.*; Hou, Z.*;Fan, Z.* Biomimeticdual-responsivebioengineerednanotheranostics forintracellularcascade-synthesizingchemo-drugs andefficientoncotherapy.J. Mater. Chem. B.,2023, 11 (1):119-130.(JCR 1区.当年影响因子:7.571)

34.Fu, X.; Yin, W.; Shi, D.; Yang, Y.; He, S.; Hai, J.; Hou, Z.;Fan, Z.*; Zhang, D.*, Shuttle-shapecarrier-freeplatinum-coordinatednanoreactors with O2self-supply and ROSaugment forenhancedphototherapy ofhypoxictumor.ACS Appl. Mater. Interfaces., 2021, 13 (28), 32690-32702.(JCR 1区.当年影响因子:10.383)

35.Shi, D.; Zhuang, J.;Fan, Z.*;Zhao, H.; Zhang, X.; Su, G.; Xie, L.*; Ge, D.*; Hou, Z.*, Self-targeting nanotherapy based on functionalized graphene oxide for synergistic thermochemotherapy.J. Colloid Interface Sci.,2021, 603:70-84.(Insidecover, JCR 1区.当年影响因子:9.965)

36.Guo, F.; Shang, J.; Zhao, H.; Lai, K.; Li, Y.;Fan, Z.*; Hou, Z.*; Su, G.*, Cube-shaped theranostic paclitaxel prodrug nanocrystals with surface functionalization of SPC and MPEG-DSPE for imaging and chemotherapy.Colloids Surf. B.,2017,160:649-660.(JCR 2区.当年影响因子:5.999)

37.Yin, W.; Fu, X.; Chang, W.; Han, L.; Meng, J.; Cao, A.; Meng, J.; Ren, X.;Fan, Z.*;Zhou, S.*, Anti-ovariancancermechanism ofesculetin:inducing G0/G1arrest andapoptosis via JAK2/STAT3signalingpathway,J. Pharm. Pharmacol.,2022,http://dx.doi.org/10.1093/jpp/rgac083.(JCR 2区.当年影响因子:4.810)


已授权专利

1.一种甲氨蝶呤金属配位聚合物及其制备方法和应用,专利号:201910970581.4。

2.一种多西紫杉醇复合缓释剂及其制备方法,专利号:ZL201711461126.9。

3.一种可分离式微针系统及模具,专利号:202420024074.8。

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