
姓名:马冶
职称/职务:讲师
专业:化学/活性筛选
研究方向:天然产物提取分离筛选及其生物活性研究
邮箱:maye@xju.edu.cn
办公室:药学院大楼408室
个人经历
学习经历:
2011.09 - 2015.06 中国药科大学生命科学与技术学院海洋药学学士
2016.09 - 2021.06 中国科学院大学化学与化工学院有机化学博士研究生
工作经历:
2021.11 - 至今 新疆大学药物研究所,专任教师
主讲课程
本科生课程:
《生物化学》
《生物化学实验》
《生理学》
研究生课程:
《新药审批与注册》
《生物医学工程导论》
主持科研项目
1.2024.01-2027.12基于p53-糖代谢途径的恰玛古萜类成分抗肺癌物质基础及作用机理,国家科技部,32万,在研
2.2023.01-2025.12天池博士计划,新疆人社厅,35万,在研
3.2025.01-2027.12黑果越橘多酚改善糖尿病肾病的物质基础及保护作用研究,新疆维吾尔自治区科技厅,5万,在研
4.2023.07-2026.12 tDCs及纳豆激酶在易栓症模型上的活性评价,新疆佳音医院,20万,在研
代表性研究成果
•Yuan Li, Wenhui Zhu, Dong Yang,Ye Ma*,Jinyao Li*, et al, Acid Residue 131 Plays a Key Role in the Catalytic Performance of Nattokinase. Journal of Agricultural and Food Chemistry. 2025, 73(28):17788-17800
•Yuan Li, Hong Wang, Kongfang Yu,Ye Ma*,Jinyao Li*, et al, Mechanism of influence of nattokinase terminal sequence on catalytic performance and molecular modification. International Journal of Biological Macromolecules, 2025. 307: p. 141872
•Yuan Li, Wenhui Zhu, Liangqi Chen,Ye Ma*and Jinyao Li*, et al. Modification of the active center of nattokinase to enhance its thermostability using a strategy based on molecular dynamics simulation, steered dynamics simulation, and conservative prediction. Frontiers in Nutrition, 2024. 11: p. 1505584.
•Ye Ma,Kejia Feng, Jiakun Wang, Huiyang Jia, Lijie Xia* and Jinyao Li*,Targeted discovery of multi-action bioactive compounds from Capparis spinosa L. for mitigating diabetic cardiomyopathy.Industrial Crops and Products, 2025, 229: 1210041
•Ye Ma,Jiakun Wang, Juyue Fan, Huiyang Jia and Jinyao Li*, Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy. Molecules, 2025. 30(1): p. 20.
•Ye Ma,Jun Li, Fei Tong, Xuelei Xin, Haji Akber Aisa, Optimization of microwave-assisted extraction using response surface methodology and the potential anti-diabeticefficacy ofNigella glanduliferaFreyn determined using the spectrum–effect relationship, Industrial Crops & Products, 2020, 153: 112592