姓名：蒋笑然

职称/职务：客座教授

专业：合成生物学

研究方向：合成生物制造细胞工厂构建；活体生物药开发

邮箱：jiangxr12@tsinghua.org.cn

个人经历

学习经历：

(1) 2012.09–2017.06，清华大学，生物学，博士

(2) 2008.09–2012.06，吉林大学，生物技术，学士

工作经历：

(1)2025.12-至今，新疆大学，药学院，客座教授

(2)2023.02-至今，陆军军医大学，基础医学院，教授

(3)2019.12-2023.01，陆军军医大学，基础医学院，副教授

(3) 2017.07-2019.11，清华大学，“博新计划”博士后

主持科研项目

1.国家自然科学基金面上项目，基于Rex转录因子的氧化还原动态调节基因线路的设计构建及其应用, 2022-01-01至2025-12-31, 55万元,主持

2.重庆英才青年拔尖人才, 3-羟基丙酸及其聚合物工业化生产最适底盘的设计与构建, 2021-11至2024-10, 50万元,主持

3.国家自然科学基金青年科学基金项目,盐单胞菌中利用廉价碳源合成3-羟基丙酸代谢通路的构建及定向进化, 2020-01-01至2022-12-31, 26万元,主持

4.博士后创新人才支持计划,利用基因振荡器在细菌中合成高性能嵌段共聚材料, 2017-07至2019-11, 60万元,主持

代表性研究成果

以第一或通讯作者发表的论文（^#第一作者；^*通讯作者）：

1.Jiang Xiao-Ran^#,WangHuan,ShenRui,Chen Guo-Qiang. Engineering the bacterial shapes for enhanced inclusion bodies accumulation.Metabolic Engineering, 2015, 29: 227-237.

2.Jiang Xiao-Ran^#, Chen Guo-Qiang. Morphology engineering of bacteria for bio-production.Biotechnology Advances, 2016; 34:435-40.

3.Jiang Xiao-Ran^#, Yao Zhi-Hao^#, Chen Guo-Qiang*. Controlling Cell Volume for Efficient PHB Production byHalomonas.Metabolic Engineering, 2017, 44: 30–37.

4.Yu Lin-Ping, Zhang Xu, Wei Dai-Xu, Wu Qiong,Jiang Xiao-Ran*,Chen Guo-Qiang*.Highly Efficient Fluorescent Material Based on Rare-Earth-Modified Polyhydroxyalkanoates.Biomacromolecules, 2019.20:3233-3241.

5.Ling Chen, Qiao Guan-Qiong, Shuai Bo-Wen, SongKun-Nan, Yao Wen-Xi,Jiang Xiao-Ran*,Chen Guo-Qiang*. Engineering Self-flocculatingHalomonas campaniensisfor Wastewaterless Open and Continuous Fermentation.Biotechnology and Bioengineering, 2019,116: 805-815.

6.ChenYong,ChenXin-Yu, Du He-Tong, Zhang Xu, Ma Yi-Ming, Chen Jin-Chun,Ye Jian-Wen*,Jiang Xiao-Ran*,Chen Guo-Qiang*. Chromosome Engineering of the TCA Cycle inHalomonas bluephagenesisfor Production of Copolymers of 3-Hydroxybutyrate and 3-Hydroxyvalerate (PHBV).Metabolic Engineering,2019,54:69-82.

7.Wang Xuan^#,Jiang Xiao-Ran^#,Wu Fu-Qing^#, Ma Yi-Ming, Che Xue-Mei, Chen Xiyue, Liu Ping, Zhang Wenbing, Ma Xi, Chen Guo-Qiang. Microbial Poly‐3‐hydroxybutyrate (PHB) as a Feed Additive for Fishes and Piglets.Biotechnology journal, 2019, 14: 1900132.

8.Yu Lin-Ping, Yan Xu, Zhang Xu, Chen Xiang-Bin, Wu Qiong,Jiang Xiao-Ran*,Chen Guo-Qiang*. Biosynthesis of Functional Polyhydroxyalkanoates by EngineeredHalomonas bluephagenesis.Metabolic Engineering,2020, 59:119-130.

9. DuHe-Tong, Zhao Yi-Qing, Wu Fu-Qing, Ouyang Pengfei, Chen Jin-Chun,Jiang Xiao-Ran*, Ye Jian-Wen*, Chen Guo-Qiang*. EngineeringHalomonasbluephagenesis for L-Threonine Production.Metabolic Engineering,2020, 60：119-127.

10.JiangXiao-Ran^#, Yan Xu^#, Yu Lin-Ping, Liu Xin-Yi, Chen Guo-Qiang. Hyperproduction of 3-hydroxypropionate byHalomonas bluephagenesis.Nature Communications, 2021, 12:1-13.

11.Xu Yan; Xu Liu; Lin-Ping Yu; Fuqing Wu;Xiao-Ran Jiang*; Guo-Qiang Chen*; Biosynthesis ofdiverse α,ω-diol-derived polyhydroxyalkanoates by engineeredHalomonas bluephagenesis,Metabolic Engineering, 2022, 72: 275-288。

12.Li-Juan Wang^#;Xiao-Ran Jiang^#; Jie Hou; Cong-Han Wang; Guo-Qiang Chen ; EngineeringHalomonas bluephagenesisvia small regulatory RNAs.,Metabolic Engineering, 2022, 73: 58-69.

13. Qixuan Su, Ping Cheng, Jiyuan Sun, Yulin Zhang, Yang Zheng,Xiao-Ran Jiang*, Xiancai Rao*. Engineering a mevalonate pathway in Halomonas bluephagenesis for the production of lycopene.Frontiers in Microbiology, 2023, 13: 1100745.

14. Yulin Zhang,Yang Zheng,Qiwen Hu,Zhen Hu,Jiyuan Sun,Ping Cheng,Xiancai Rao*,Xiao-Ran Jiang*. Simultaneous multiplex genome loci editing of Halomonas bluephagenesis using an engineered CRISPR-guided base editor [J].Synthetic andSystemBiotechnology, 2024, 9(3): 586−593.

15. Ji-yuan Sun,Xiao-Ran Jiang*. Morphology engineering facilitates constructing efficient cell factories.Biotechnology Advances, 2025: 108639.

16. Xiong Xiang, Ziwei Zhou, Xiancai Rao*,Xiao-Ran Jiang*. Recent advances of engineered bacteria for therapeutic applications.Molecular Therapy, 2026, 34(2): 714-733.